Brian M. Bennett, Queen’s University
Department of Biomedical and Molecular Sciences
Professor
Kingston, Ontario
bennett@queensu.ca
Office:
(613) 533-6000 ext. 36473
Expert In
Bio/Research
Vascular biotransformation of organic nitrates (eg. nitroglycerin) to an activator of guanylyl cyclase appears to be prerequisite for vasodilation, whereas tolerance development to organic nitrates is associated with a decrease in this biotransformation.