Graham Holloway, University of Guelph

Profile photo of Graham Holloway, expert at University of Guelph

Associate Dean Research, College of Biological Science Professor Guelph, Ontario ghollowa@uoguelph.ca Office: (519) 824-4120 ext. 53688
(519) 824-4120 ext. 56654

Bio/Research

Dr. Holloway's research focuses on understanding the regulation of mitochondrial fatty acid oxidation (breakdown of fat yielding energy) in skeletal and cardiac muscle, which can be influenced by 1) the transport of fat into mitochondria and 2) mitochondrial content. Holloway uses a variety of te...

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Bio/Research

Dr. Holloway's research focuses on understanding the regulation of mitochondrial fatty acid oxidation (breakdown of fat yielding energy) in skeletal and cardiac muscle, which can be influenced by 1) the transport of fat into mitochondria and 2) mitochondrial content. Holloway uses a variety of techniques to examine mitochondrial function (isolated mitochondria, permeabilized fibres, whole muscle incubations), use molecular biological approaches to up-and down-regulate mitochondrial proteins, as well exercise and aerobic training to study what regulates mitochondrial fatty acid oxidation. Holloway's lab applies this knowledge to the study human exercise performance as well as type 2 diabetes, a condition that has been speculated to have alterations in mitochondria as a key event in the progression and/or development of this disease.

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