Our research group investigates the formation of the vertebrate central nervous system, with a focus on identifying cell to cell signaling mechanisms in the brainstem and eye. These projects utilize zebrafish as a model system, a vertebrate that is easily grown in large numbers, whose genome is l...
Our research group investigates the formation of the vertebrate central nervous system, with a focus on identifying cell to cell signaling mechanisms in the brainstem and eye. These projects utilize zebrafish as a model system, a vertebrate that is easily grown in large numbers, whose genome is largely sequenced, and for which robust gene manipulation tools permit the rapid creation of transgenics and knockdowns. Our research laboratory studies three diverse fields: (1) formation of the zebrafish eye with a goal of identifying genes that control the identities of retinal ganglion cells; (2) cell-cell signaling that regulates regional identity in the developing brainstem (hindbrain) with a goal of identifying models for human cranial dysinnervation disorders; and (3) broader studies on the genes involved in eye and brain formation, with a focus on leukemia-causing oncogenes.