Honig, a biophysicist, has developed tools to help predict the structure and function of biological macromolecules, which are large molecules such as proteins. He is noted for innovating methods to compute and display the electrostatic potentials of macromolecules based on their 3D structures; th...
Honig, a biophysicist, has developed tools to help predict the structure and function of biological macromolecules, which are large molecules such as proteins. He is noted for innovating methods to compute and display the electrostatic potentials of macromolecules based on their 3D structures; the computer programs DelPHi and GRASP were developed in his laboratory and are used by the academic and industrial communities. His recent work aims to predict the shape of proteins based on their amino acid sequence and understand the physical forces that lead proteins to bind to other proteins, membranes and DNA.