The Coombes laboratory investigates the genetics and molecular pathogenesis of human and animal infectious diseases. Coombes lab scientists use genetic, genomic and proteomics techniques to understand how bacterial virulence factors are expressed and function in the context of a host. We use mode...
The Coombes laboratory investigates the genetics and molecular pathogenesis of human and animal infectious diseases. Coombes lab scientists use genetic, genomic and proteomics techniques to understand how bacterial virulence factors are expressed and function in the context of a host. We use model systems to then understand the complexity of the biological processes affected by these virulence factors, including subversion of the immune system, colonization dynamics and host damage. We have initiated research projects in four major areas that focus on the evolution, mechanisms and host responses to pathogenic processes caused by bacteria.