Brian Ward, McGill University
Associate Professor
Centre for the Study of Host Resistance
Microbiology & Immunology
Montreal, Quebec
brian.ward@mcgill.ca
Office:
(514) 934-8049
Expert In
Bio/Research
I am very interested in basic studies of the correlates of immune protection as well as the immunologic correlates of vaccine-associated adverse events. Using measles as our primary model, we have examined immune responses generated following natural infection and vaccination in children of the d...
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Bio/Research
I am very interested in basic studies of the correlates of immune protection as well as the immunologic correlates of vaccine-associated adverse events. Using measles as our primary model, we have examined immune responses generated following natural infection and vaccination in children of the developed and the developing world. Adverse events after vaccination are a growing concern and the lab has been involved and continues to be involved in studies of adverse events after vaccines for measles (increased mortality after the high titer formulation, autism and Crohns Disease after MMR), pertussis (local and systemic reactions), anthrax (all events), smallpox (death) and influenza (oculo-respiratory syndrome). We are also very interested in the interactions between virus (measles and HIV are our models) and retinoids both in vitro and in the field (Zimbabwe, Peru). We are developing proteosome-based vaccines (nasal delivery) for several respiratory viruses (measles, RSV, PIV3) as well as Toxoplasma gondii (Tg-AMA1) and Leishmania donovani (A2). Finally, we have an active Vaccine Evaluation Center that recruits subjects to ‘first-in-man’ Phase I and Phase II studies. In 2003, we studied a CpG-based hepatitis B vaccine, a pan-serotype, protein-based Streptocossus pneumoniae vaccine and a trivalent proteosome-based influenza vaccine.
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