The focus of this program is to identify the genes involved in the radiation-induced lung diseases of pneumonitis (alveolitis) and fibrosis. We have mapped murine strain differences in propensity to develop lung d...
The focus of this program is to identify the genes involved in the radiation-induced lung diseases of pneumonitis (alveolitis) and fibrosis. We have mapped murine strain differences in propensity to develop lung disease in a C57BL/6J and C3H mouse model and are currently using genetic variation defined in the mouse Hap Map, along with gene expression data and siRNA investigations to identify the underlying causal genetic variations. We are also collaborating with the Division of Radiation Oncology to investigate whether these genetic variations, identified in mice, predict for the normal tissue side effect in the clinic.
Project 2 (Cystic Fibrosis):
The focus of this research program is to determine whether the intestinal microbiome of Cftr deficient mice influences the lung and intestinal disease which develops in this model. These studies include characterization of the intestinal microbiome of cystic fibrosis mice using Illumina sequencing technology.