The primary interest of the Alabi group is to facilitate the development and translation of nanoparticle therapeutics by elucidating the underlying principles that dictate their macromolecular interactions and transport in complex biological environments. To this end, our research will fall along...
The primary interest of the Alabi group is to facilitate the development and translation of nanoparticle therapeutics by elucidating the underlying principles that dictate their macromolecular interactions and transport in complex biological environments. To this end, our research will fall along two major themes: 1) the development of a multiparametric characterization tool that enables functional analysis of the nanoparticle surface composition. This surface characterization should facilitate our understanding of the macromolecular properties that drive in vivo biodistribution patterns, which can ultimately be leveraged towards the rational design of tissue specific therapeutics. 2) the design of molecular/polymeric conjugates that can aid our understanding of intracellular trafficking pathways and facilitate intracellular transport from endocytic vesicles to the desired intracellular target location.