I am currently the principal investigator and Professor of Ophthalmology, Faculty of Medicine, at UBC. I hold associate member status in Experimental Medicine and the Graduate Program in Neuroscience and am a non-resident member of Green College.
I am currently the principal investigator and Professor of Ophthalmology, Faculty of Medicine, at UBC. I hold associate member status in Experimental Medicine and the Graduate Program in Neuroscience and am a non-resident member of Green College.
I began my post-secondary education in California with a B.Sc. in Biology from the University of California Irvine. I continued my education at the Hebrew University of Jerusalem with a M.Sc. in Medical Physiology and a Ph.D. in Neurobiology. I then spent eight years at Dalhousie University (Psychology), first as a post-doctoral fellow, and then as a research associate, before beginning my affiliation with UBC in 1988.
My research over the years has focussed on two key areas: neuroplasticity and neuropathology. When I first arrived at UBC, most of my work was directed toward an understanding of the mechanisms underlying receptor regulation. This work resulted in numerous journal articles and reviews. The outcome of these studies laid the groundwork for a re-evaluation of current theories of neuroplastic phenomenon such as long-term potentiation, and for the role that abnormal receptor regulation may play in some neurodegenerative disorders.
An ongoing research focus of my laboratory is on ALS-parkinsonism dementia complex. Most of our past and current studies target various facets of this neurodegenerative disease through our mouse model using identified neurotoxins (various phtyosteryl glucosides and aluminum). Our more recent work has begun to look at aluminum toxicity from vaccine adjuvants and the impact on the developing and mature nervous system.