Cellular interactions with their surrounding including other cells and extracellular matrix are critically important in the development and progression of cancer. However, current cancer research mostly studies cells under conditions that do not reflect the microenvironmental context that cells e...
Cellular interactions with their surrounding including other cells and extracellular matrix are critically important in the development and progression of cancer. However, current cancer research mostly studies cells under conditions that do not reflect the microenvironmental context that cells experience in the body. By exploring tissue engineering, microfabrication, and biomaterials strategies the Fischbach-Teschl lab engineers culture models that allow studying tumor cells under conditions that mimic those within patients. In particular, the Fischbach-Teschl lab uses these model systems to gain a better understanding of the biological and physical principles that tumors use to modulate the function of blood vessels, stem cells, and bone metastatic sites, all parameters ultimately contributing to increased cancer aggressiveness and worse clinical prognosis.