David G. Huntsman, University of British Columbia
Pathology and Laboratory Medicine
Professor
Vancouver, British Columbia
dhuntsma@bccancer.bc.ca
Office:
(604) 877-6000 ext. 2148
Bio/Research
Dr. Huntsman has active research programs which are focused on hereditary gastric cancer and the development of predictive and prognostic tissue-based cancer biomarkers for a wide variety of tumour types. His gastric cancer research has resulted in the discovery of over half of known CDH1 (a here...
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Bio/Research
Dr. Huntsman has active research programs which are focused on hereditary gastric cancer and the development of predictive and prognostic tissue-based cancer biomarkers for a wide variety of tumour types. His gastric cancer research has resulted in the discovery of over half of known CDH1 (a hereditary diffuse gastric cancer susceptibility gene) mutations. In addition, his pathologic study of specimens from prophylactic gastrectomies uncovered the common presence of occult gastric carcinomas; this alerted the medical community to the lack of sensitivity of standard endoscopic screening for diffuse gastric cancer detection. Dr. Huntsman was also a member of the research team that discovered EMSY, a BRCA2 interacting protein. The amplification of the EMSY gene is clinically significant in breast and possibly ovarian cancers and overexpression of a truncated form of EMSY results in dramatic chromosomal instability.Through the development of CTAG and GPEC Dr. Huntsman has combined a unique business opportunity for therapeutic and diagnostic research.As collaboration is critical for effective translational research, Dr. Huntsman is happily engaged with a number of multidisciplinary research groups, including the Prostate Centre at Vancouver General Hospital.
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