Bio/Research
Our primary research goals are directed towards understanding the mechanism by which adhesion-type G-protein-coupled receptors (GPCRs) function in the brain, and deciphering the role of the newly discovered GAIN domain in their function using a combination of biophysical, biochemical and cell bio...
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Bio/Research
Our primary research goals are directed towards understanding the mechanism by which adhesion-type G-protein-coupled receptors (GPCRs) function in the brain, and deciphering the role of the newly discovered GAIN domain in their function using a combination of biophysical, biochemical and cell biological approaches. GPCRs are important signaling molecules and are among the most commonly targeted group of molecules for treatment of human diseases. Adhesion GPCRs are a new GPCR family with emerging roles in multiple brain functions and disorders such as brain development, synapse maturation/elimination, bilateral frontoparietal polymicrogyria (BFPP, a neurodevelopmental disorder) and attention-deficit hyperactivity disorder. Better understanding of how adhesion GPCRs function could lead to targeted treatments for various brain diseases.
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