Donglin Bai, Western University
Assistant Professor
Physiology and Pharmacology
London, Ontario
donglin.bai@schulich.uwo.ca
Office:
(519) 850-2569 ext. 82569
Bio/Research
I am interested in defining the functional domains/residues of connexin molecule in determining the gap junction channel properties, such as docking, Vj-gating, single channel conductance, and delineating how gap junction mutants causing human diseases. We use molecular engineering method to gene...
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Bio/Research
I am interested in defining the functional domains/residues of connexin molecule in determining the gap junction channel properties, such as docking, Vj-gating, single channel conductance, and delineating how gap junction mutants causing human diseases. We use molecular engineering method to generate mutant connexins and use dual patch clamp, dye-transfer and fluorescent imaging techniques to investigate the functional outcomes. We also use genetically modified mouse models to study the functional defects of gap junction mutants in vivo.
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