Frieder Schoeck, McGill University
Associate Professor
Biology
Montreal, Quebec
frieder.schoeck@mcgill.ca
Office:
(514) 398-6434
Bio/Research
We study cell-matrix adhesion and the actomyosin cytoskeleton, in particular, how integrin-associated proteins regulate adhesion during muscle attachment and how myofibrils assemble in the fruit fly Drosophila melanogaster. We use Drosophila as a model system because of its unique genetics, which...
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Bio/Research
We study cell-matrix adhesion and the actomyosin cytoskeleton, in particular, how integrin-associated proteins regulate adhesion during muscle attachment and how myofibrils assemble in the fruit fly Drosophila melanogaster. We use Drosophila as a model system because of its unique genetics, which allows us to study the relationship and function of genes in tissues, and because of the high homology of basic cellular processes between Drosophila and humans. We study muscle assembly, because of the highly repetitive and regular, almost crystalline array of sarcomeres that make up the actomyosin cytoskeleton of a myofibril (Fig. 1); we study integrin-mediated muscle attachment, because myotendinous junctions must withstand very strong forces and are therefore a sensitive system to detect and investigate adhesion defects.
Our research will shed light on the regulation of integrin adhesion and the assembly of the actomyosin cytoskeleton in differentiating muscles. This will lead to a better understanding of muscle disorders and their underlying basic cell biology.
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Our research will shed light on the regulation of integrin adhesion and the assembly of the actomyosin cytoskeleton in differentiating muscles. This will lead to a better understanding of muscle disorders and their underlying basic cell biology.
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