My lab is investigating the mechanisms by which photosynthetic organisms sense and respond to environmental change, using cyanobacterial RNA helicases as our model system. Expression of two distinct RNA helicases is regulated specifically by light induced alterations in the redox status of the pl...
My lab is investigating the mechanisms by which photosynthetic organisms sense and respond to environmental change, using cyanobacterial RNA helicases as our model system. Expression of two distinct RNA helicases is regulated specifically by light induced alterations in the redox status of the plastoquinone pool or alterations in temperature (cold shock). Since RNA helicases unwind dsRNA (inactive) to produce ssRNA which is functional, they have the potential to regulate translation, thereby linking environmentally induced changes in gene transcription with control at the translational level. The research involves an integrated approach using molecular, biochemical and physiological techniques.