We are primarily interested in two main fields of research: the allosteric conformational switches that control signaling pathways and the early steps of amyloid fibril formation.
Allosteric conformational switches in signaling pathways: We are currently mapping the intra-molecular signaling pathways and the dynamic changes that propagate the signal carried by second messengers. So far our work has focused mainly on the prototypical receptor for cAMP, i.e. protein kinase A, and specifically on a single cAMP-binding domain of PKA that controls the inhibition of PKA in a cAMP-dependent manner.
Early steps of amyloid fibril formation: We are currently investigating the mechanism of nucleation and of inhibition of amyloid fibrils. So far our work in this field has mainly focused on the Ab system and on endogenous proteins that inhibit its pathogenic oligomerization.