Graham Holloway, University of Guelph

Associate Professor Guelph, Ontario ghollowa@uoguelph.ca Office: (519) 824-4120 ext. 53688

Bio/Research

Prof Holloway's research has been focused on understanding the regulation of mitochondrial fatty acid oxidation (breakdown of fat yielding energy) in skeletal and cardiac muscle, which can be influenced by 1) the transport of fat into mitochondria and 2) mitochondrial content. Prof Holloway uses ...

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Bio/Research

Prof Holloway's research has been focused on understanding the regulation of mitochondrial fatty acid oxidation (breakdown of fat yielding energy) in skeletal and cardiac muscle, which can be influenced by 1) the transport of fat into mitochondria and 2) mitochondrial content. Prof Holloway uses a variety of techniques to examine mitochondrial function (isolated mitochondria, permeabilized fibres, whole muscle incubations), use molecular biological approaches to up-and down-regulate mitochondrial proteins, as well exercise and aerobic training to study what regulates mitochondrial fatty acid oxidation. We apply this knowledge to the study human exercise performance as well as type 2 diabetes, a condition that has been speculated to have alterations in mitochondria as a key event in the progression and/or development of this disease.

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