Hans Schreiber, University of Chicago
Professor
Chicago, Illinois
hszz@uchicago.edu
Office:
(773) 702-9204
Expert In
Bio/Research
Some of the ongoing projects in my laboratory are: 1. Identification of the genetic origins, molecular biology and function of tumor-specific antigens. 2. Development of novel strategies focusing on truly cancer-specific targets to destroy long-term established cancers. We are studying the use of...
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Bio/Research
Some of the ongoing projects in my laboratory are: 1. Identification of the genetic origins, molecular biology and function of tumor-specific antigens. 2. Development of novel strategies focusing on truly cancer-specific targets to destroy long-term established cancers. We are studying the use of recombinant high affinity T cell receptors or antibody receptors as effectors or as vehicles for molecules. Such reagents can kill the cancer cell or detect it by imaging. 3. Study of the tumor microenvironment, tumor stroma, and mechanisms of a local tumor barrier and of paracrine stimulation of tumor growth. Approaches of targeting tumor stroma and tumor vessels for destruction. 4. Mechanism of long-lasting growth arrest of cancer in the absence of T cells or antibodies by certain cytokines, tumor necrosis factor and interferon gamma in particular. 5. Development of approaches to immune prevention of cancer development in cancer-prone individuals by the deletion of initiated cells harboring oncogenes. We have generated novel transgenic models for this purpose. 6. Developing new means to prevent cancer recurrence by therapy-resistant escape variants and to eliminate residual micro-disseminated cancer cells to prevent relapse remaining in individuals following surgery, radiotherapy or chemotherapy.
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