Cell-free DNA: When cells turn over in body tissue, their genomes persist for some time in circulation in the form of cell-free DNA. Cell-free DNA is abundantly present in plasma and provides an information-rich window into human physiology, with rapidly expanding applications in cancer diagnosis...
Cell-free DNA: When cells turn over in body tissue, their genomes persist for some time in circulation in the form of cell-free DNA. Cell-free DNA is abundantly present in plasma and provides an information-rich window into human physiology, with rapidly expanding applications in cancer diagnosis and treatment monitoring, prenatal diagnosis, and monitoring of rejection in transplantation. The lab develops assays to interrogate cell-free DNA via sequencing, with an eye on improved accuracy, lower cost and blood volume requirements, and new applications in clinical diagnostics.