Jack Jhamandas, University of Alberta
Department of Medicine
Professor
Edmonton, Alberta
jack.jhamandas@ualberta.ca
Office:
(780) 492-7153
Expert In
Bio/Research
A major focus of our research relates to investigating the mechanisms whereby amyloid protein (A ), a 39-43 amino acid peptide that is abnormally expressed in the brains of Alzheimer’s disease patients, produces a selective loss of cholinergic neurons in the basal forebrain. Specifically, we are ...
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Bio/Research
A major focus of our research relates to investigating the mechanisms whereby amyloid protein (A ), a 39-43 amino acid peptide that is abnormally expressed in the brains of Alzheimer’s disease patients, produces a selective loss of cholinergic neurons in the basal forebrain. Specifically, we are examining, the ionic and signal transduction mechanisms underlying the selective effects of A on cholinergic basal forebrain neurons. Nicotinic acetylcholine receptors and the amylin receptor are potential targets for A actions in the brain. We are therefore investigating whether A neurotoxicity in the CNS is expressed through these receptors and the potential use of anti-amyloid activity as neuroprotective agents in treatment of AD.
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