James Squires, University of Guelph

Profile photo of James Squires, expert at University of Guelph

Chair of the Dept. of Animal Biosciences Professor Guelph, Ontario jsquires@uoguelph.ca Office: (519) 824-4120 ext. 53928

Bio/Research

Prof Squires broad research interests are in metabolism and functional genomics. Of particular interest is the metabolism of boar taint compounds and factors that affect their production and catabolism. His lab has identified some of the key enzymes involved in the metabolic pathways for skatole ...

Click to Expand >>

Bio/Research

Prof Squires broad research interests are in metabolism and functional genomics. Of particular interest is the metabolism of boar taint compounds and factors that affect their production and catabolism. His lab has identified some of the key enzymes involved in the metabolic pathways for skatole and androstenone. We are characterizing the substrate and inhibitor specificity of a number of porcine CYP450s and phase II enzymes, and are studying the role of nuclear receptors CAR, PXR and FXR in the pig, including their ligand specificity, the role of splice variants, and the downstream effects of receptor activation.

Squires' lab has identified a number of polymorphisms in candidate genes that code for key enzymes involved in the metabolism of boar taint compounds. We are particularly interested in polymorphisms that affect the function of these enzymes and thus dramatically affect the trait, and are developing a SNP panel that will be used for genetic selection for low boar taint lines of pigs. They are also working with collaborators to develop panels of genetic markers for other desirable traits, including improved disease resistance and increased productivity (feed efficiency, growth performance, and meat quality). They are also working with collaborators on hemostasis and metabolic diseases in poultry. Based on the similarities in phase I and II metabolism and nuclear receptor function between pigs and humans, we are developing a porcine hepatocyte model for toxicology and metabolic disease studies relevant to humans.


Click to Shrink <<

Links