Jean-marc Renaud, University of Ottawa
Associate Professor
Cellular and Molecular Medicine
Ottawa, Ontario
jmrenaud@uottawa.ca
Office:
(613) 562-5800 ext. 8156
(613) 562-5800 ext. 8397
Expert In
Bio/Research
Everyone has felt the effect of fatigue in our muscle when we do exercise. For more than a century scientists have tried to elucidate the mechanisms of muscle fatigue. For a long time, changes in metabolites, such as ATP, H + and lactate, were thought to reduce force production by the contractile...
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Bio/Research
Everyone has felt the effect of fatigue in our muscle when we do exercise. For more than a century scientists have tried to elucidate the mechanisms of muscle fatigue. For a long time, changes in metabolites, such as ATP, H + and lactate, were thought to reduce force production by the contractile components and thus be responsible for the decrease in force during fatigue. Surprisingly, recent studies have now demonstrated that neither ATP, H + nor lactate may be responsible for the decrease in force. Even more exciting is the fact that lactate and acidic pH may in fact protect muscle against the fatigue process! As a consequence of these new findings, we must now study how muscle contractility is regulated not only during fatigue but throughout the entire exercise process. This constitutes one of the major research projects in this laboratory.
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