The research being conducted in my laboratory aims to identify the pathogenetic mechanisms involved in systemic autoimmune diseases using a mouse model that develops a spontaneous lupus nephritis that is very similar to human SLE. We are also investigating whether estrogen receptor expression on ...
The research being conducted in my laboratory aims to identify the pathogenetic mechanisms involved in systemic autoimmune diseases using a mouse model that develops a spontaneous lupus nephritis that is very similar to human SLE. We are also investigating whether estrogen receptor expression on immune cells is responsible, in part, for gender bias in immune responses, including autoimmune disease. Exposure to some toxic chemicals that behave like estrogen, such as dioxin, has been suggested to induce and/or modulate autoimmune diseases including SLE and diabetes, and we are determining whether these exposures are triggers or modulators of SLE.