Our laboratory studies Bacillus subtilis, a Gram-positive soil bacterium and genetic model system. Major research efforts address the stress responses elicited by (i) antibiotics that affect the cell envelope, (ii) reactive oxygen species, or (iii) deficiency or excess of nutrient metal ions. For...
Our laboratory studies Bacillus subtilis, a Gram-positive soil bacterium and genetic model system. Major research efforts address the stress responses elicited by (i) antibiotics that affect the cell envelope, (ii) reactive oxygen species, or (iii) deficiency or excess of nutrient metal ions. For each stress response, we are interested in the global patterns of transcriptional control, the mechanisms of the corresponding regulatory proteins, and the roles of the induced pathways.