Dr. Denburg's main research thrusts include examination of the mechanisms of allergic inflammation, with particular emphasis on hemopoietic cytokines and their role in activating the differentiation and recruitment of inflammatory cells such as eosinophils, basophils and mast cells. This includes...
Dr. Denburg's main research thrusts include examination of the mechanisms of allergic inflammation, with particular emphasis on hemopoietic cytokines and their role in activating the differentiation and recruitment of inflammatory cells such as eosinophils, basophils and mast cells. This includes an understanding of the growth and differentiation of human basophil and eosinophil precursors, with the development of in vitro assays to monitor clinically relevant fluctuations in these cells during allergic responses. The specific diseases studied have included allergic rhinitis, nasal polyposis and asthma. Currently, the focus of his research is the development of allergic disease and asthma through the study of cord blood stem cells. Additionally in several national projects undertaken by AllerGen NCE, hemopoietic progenitor phenotyping has been utilized to discover new biomarkers to predict the development of allergic disease and asthma.
As Scientific Director of AllerGen, Dr. Denburg helps steer the innovative and inter-disciplinary research program involving research partners in academic, public and private sectors, representing expertise in medicine, genetics, molecular biology (genomics and proteomics); environmental, occupational and population health; epidemiology; health economics, and health policy; ethics, psychology, sociology, and medical geography and anthropology, aimed at understanding both the physiological and psychosocial aspects of allergic/immune diseases.