Judith West-Mays, McMaster University
Department of Pathology & Molecular Medicine
Professor
Hamilton, Ontario
westmayj@mcmaster.ca
Office:
(905) 525-9140 ext. 26237
Expert In
Bio/Research
The general objective of my research program is to identify the genes and molecular mechanisms involved in development and differentiation of the eye, and further determine how these mechanisms may be perturbed in blinding ocular disease.
My research focuses on three central themes relat...
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My research focuses on three central themes relat...
Click to Expand >>
Bio/Research
The general objective of my research program is to identify the genes and molecular mechanisms involved in development and differentiation of the eye, and further determine how these mechanisms may be perturbed in blinding ocular disease.
My research focuses on three central themes related to ocular disorders: 1) The role of candidate disease genes (transcription factor AP-2) in development and differentiation of the eye and in congenital ocular disorders; 2) Role of TGFb and Matrix Metalloproteinases in subcapsular cataract formation. 3) Establishment of neuroprotectants for retinal degenerative disorders including diabetic retinopathy, age-related macular degeneration, glaucoma and retinitis pigmentosa.
Methodologies include genetically targeted approaches in mice (transgenics, conditional mutants; null mutants), analyses of phenotypes using molecular and immunohistochemical approaches and cell culture models. We predict that these studies will lead to therapeutic strategies (via vitreal implants or gene therapy approaches) for correcting or preventing vision loss.
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My research focuses on three central themes related to ocular disorders: 1) The role of candidate disease genes (transcription factor AP-2) in development and differentiation of the eye and in congenital ocular disorders; 2) Role of TGFb and Matrix Metalloproteinases in subcapsular cataract formation. 3) Establishment of neuroprotectants for retinal degenerative disorders including diabetic retinopathy, age-related macular degeneration, glaucoma and retinitis pigmentosa.
Methodologies include genetically targeted approaches in mice (transgenics, conditional mutants; null mutants), analyses of phenotypes using molecular and immunohistochemical approaches and cell culture models. We predict that these studies will lead to therapeutic strategies (via vitreal implants or gene therapy approaches) for correcting or preventing vision loss.
Click to Shrink <<