Kenneth Baimbridge, University of British Columbia
Cellular and Physiological Sciences
Professor
Vancouver, British Columbia
baim@interchange.ubc.ca
Office:
(604) 822-2330
(604) 822-9235
Bio/Research
The general theme of my research is the physiological and pathophysiological role of calcium in the central nervous system. Central to these studies are the actions of neuron specific calcium-binding proteins in the regulation of intracellular calcium ion concentration and in mediating the action...
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Bio/Research
The general theme of my research is the physiological and pathophysiological role of calcium in the central nervous system. Central to these studies are the actions of neuron specific calcium-binding proteins in the regulation of intracellular calcium ion concentration and in mediating the actions of calcium as a second messenger system. I have mostly been involved with work investigating calbindin D-28k, (formerly known as calcium-binding protein; CaBP) and parvalbumin (PV). Both proteins were originally discovered in peripheral tissues (gut and muscle, respectively), but are also found in discrete neuronal populations within the CNS. Since these proteins have not been shown to have modulatory actions similar to calmodulin they are thought to act as intracellular calcium buffering proteins.
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