Lois M. Mulligan, Queen’s University
Cancer Research Institute
Medicine
Professor
Kingston, Ontario
mulligal@queensu.ca
Office:
(613) 533-6000 ext. 77475
Bio/Research
The primary interests of our group is in the relationship between the processes of normal and neoplastic growth. We are interested in dissecting the genetic events responsible for diseases that disrupt normal developmental patterns. Our specific area of interest is in the role of the RET proto-on...
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Bio/Research
The primary interests of our group is in the relationship between the processes of normal and neoplastic growth. We are interested in dissecting the genetic events responsible for diseases that disrupt normal developmental patterns. Our specific area of interest is in the role of the RET proto-oncogene.Mutations in the RET gene are involved in the inherited cancer syndromemultiple endocrine neoplasia type 2 (MEN 2) and also in a common birth defect which affects the formation of nerves in the developing gut. Early recognition of these diseases, by identifying RET mutations, allows treatment before symptoms or complications develop which reduces morbidity and death for these patients. However, not all disease cases have detectable RET mutations. We need to identify new genes or mechanisms that might account for these diseases cases and allow us to improve our ability to diagnose prevent or treat the disease in these patients. Our lab is investigating the normal functions of RET and the molecules with which it interacts in development of neural cell types and in tumours of neuorendocrine cell types.
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