Margaret Fahnestock, McMaster University
Department of Psychiatry and Behavioural Neurosciences
Professor
Hamilton, Ontario
fahnest@mcmaster.ca
Office:
(905) 525-9140 ext. 23344
Expert In
Bio/Research
Regulation of neurotrophic factors and their precursors. Role and regulation of NGF and BDNF in Alzheimer’s disease, epilepsy, and autism. Peripheral nerve injury.
Dr. Fahnestock's laboratory uses molecular techniques to study proteins essential for nervous system development, plasticity...
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Dr. Fahnestock's laboratory uses molecular techniques to study proteins essential for nervous system development, plasticity...
Click to Expand >>
Bio/Research
Regulation of neurotrophic factors and their precursors. Role and regulation of NGF and BDNF in Alzheimer’s disease, epilepsy, and autism. Peripheral nerve injury.
Dr. Fahnestock's laboratory uses molecular techniques to study proteins essential for nervous system development, plasticity and function. Her research interests centre on the regulation and biosynthesis of neurotrophic factors and their involvement in neurodegenerative diseases. Neurotrophic factors such as nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) are necessary for peripheral and central nervous system development, maintenance and response to injury. The levels of these factors are tightly controlled in a tissue-specific manner. Their biological activity is regulated by a number of processes including transcriptional regulation, proteolytic processing of precursors, and binding to inhibitors and receptors. Her laboratory is attempting to dissect the mechanisms that regulate NGF and BDNF biosynthesis using both rodent and human experimental systems, with a particular focus on human CNS conditions such as Alzheimer's disease.
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Dr. Fahnestock's laboratory uses molecular techniques to study proteins essential for nervous system development, plasticity and function. Her research interests centre on the regulation and biosynthesis of neurotrophic factors and their involvement in neurodegenerative diseases. Neurotrophic factors such as nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) are necessary for peripheral and central nervous system development, maintenance and response to injury. The levels of these factors are tightly controlled in a tissue-specific manner. Their biological activity is regulated by a number of processes including transcriptional regulation, proteolytic processing of precursors, and binding to inhibitors and receptors. Her laboratory is attempting to dissect the mechanisms that regulate NGF and BDNF biosynthesis using both rodent and human experimental systems, with a particular focus on human CNS conditions such as Alzheimer's disease.
Click to Shrink <<