Mechanisms of molecular regulation of key enzymes of cysteine metabolism in response to dietary changes; development and characterization of tissue-specific cysteine dioxygenase "knockout" mice; structure-function studies of thiol dioxygenases (cysteine dioxygenase, cysteamine dioxygenase); tissu...
Mechanisms of molecular regulation of key enzymes of cysteine metabolism in response to dietary changes; development and characterization of tissue-specific cysteine dioxygenase "knockout" mice; structure-function studies of thiol dioxygenases (cysteine dioxygenase, cysteamine dioxygenase); tissue-specific expression and function of enzymes in taurine and hydrogen sulfide biosynthetic pathways; amino acid deprivation and response to stress; role of amino acids in sensing of nutrient deprivation and activation of stress response pathways.