Maureen Hanson, Cornell University
Professor
Ithaca, New York
mrh5@cornell.edu
Office:
(607) 254-4833
Expert In
Bio/Research
Dr. Hanson has two different research programs, related through their dependence on modern methods for examining genome sequences and gene expression. Her research in plant biology has always focused on the genome-containing organelles of plants, chloroplasts and mitochondria. Reflecting their pr...
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Bio/Research
Dr. Hanson has two different research programs, related through their dependence on modern methods for examining genome sequences and gene expression. Her research in plant biology has always focused on the genome-containing organelles of plants, chloroplasts and mitochondria. Reflecting their prokaryotic origins, gene expression in these organelles differs from that of nuclear genes. In particular, organelle genes are often organized in operons that undergo considerable post-transcriptional processing, including RNA editing. The nuclear genome exerts significant control of organelle gene expression through the action of nuclear-encoded proteins targeted to the organelle. Research goals include identification of the components of the organelle RNA editing apparatus and an RNA/protein complex that suppresses the expression of an abnormal mitochondrial protein. Another study aims to identify proteins that control the morphology and movement of organelles. A third project concerns expression of bacterial microcompartments in chloroplasts in order to enhance the efficiency of photosynthesis. A second research area is the pathophysiology of the human illness Chronic Fatigue Syndrome, also known as Myalgic Encephalomyelitis. Individuals with this illness often have gastrointestinal issues and evidence of immune system activation and dysfunction. One current project involves characterization of the gut and blood microbiome in healthy vs. ill subjects. Another project aims to identify differences in gene expression at baseline and following exercise in healthy and in subjects diagnosed with CFS/ME.
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