Bio/Research
Dr. Gack’s research focuses on understanding how the intricate interplay between viruses and the host's immune system impacts the outcome of viral infection and disease. Understanding host-virus interactions at a molecular level is an essential step in developing safe and effective antivirals and...
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Bio/Research
Dr. Gack’s research focuses on understanding how the intricate interplay between viruses and the host's immune system impacts the outcome of viral infection and disease. Understanding host-virus interactions at a molecular level is an essential step in developing safe and effective antivirals and vaccines. A long-term goal of her research is to identify the strategies employed by viral pathogens – influenza virus, dengue virus and several tumor viruses – to escape cell-intrinsic immune responses. On the other hand, she is identifying and functionally characterizing novel host factors that play important roles in the antiviral immune defense. Her laboratory uses an integrative approach that combines proteomics and RNAi screens with molecular, biochemical, and cell-biological approaches as well as reverse genetics systems for the generation of recombinant mutant viruses.
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