My research is aimed at understanding how the formation and development of presynaptic and postsynaptic specializations are regulated during nerve-muscle synaptogenesis. Currently our focus is on the development and alignment of presynaptic active zones and postsynaptic junctional folds. This wor...
My research is aimed at understanding how the formation and development of presynaptic and postsynaptic specializations are regulated during nerve-muscle synaptogenesis. Currently our focus is on the development and alignment of presynaptic active zones and postsynaptic junctional folds. This work is carried out on cultures of embryonic Xenopus nerve and muscle cells as well as on neuromuscular junctions formed in vivo. Fluorescent staining and microscopy is used to assess the distribution of the specific synaptic molecules.