Patricia N. Tonin, McGill University

Associate Professor Medicine Montreal, Quebec patricia.tonin@mcgill.ca

Bio/Research

Over the past 10 years I have worked on the contribution of BRCA1 and BRCA2 in the French Canadian population of Quebec. We were the first to report the recurrence of specific mutations in this population. Additional studies relate to the phenotypic characterization of hereditary breast/ovarian c...

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Bio/Research

Over the past 10 years I have worked on the contribution of BRCA1 and BRCA2 in the French Canadian population of Quebec. We were the first to report the recurrence of specific mutations in this population. Additional studies relate to the phenotypic characterization of hereditary breast/ovarian cancer families to further dissecting the contribution of these known genes with the long-term aim to identify novel highly penetrant cancer susceptibility genes. In addition, we research sporadic molecular genetic events in ovarian cancer. Using loss of heterozygosity analysis, expression microarrray analyses and chromosome transfer techniques we aim to determine the contribution of chromosome 3 and 17 tumour suppressor genes in ovarian cancer. The long-term goal is to identify markers for ovarian cancer pathogenesis. Other collaborative projects include: the application of expression microarray techniques to identify ovarian cancer markers, and the application of nonsense mediated decay strategies towards the identification of novel tumour suppressor genes in breast cancers.

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