The main research focus in the Petkovich lab is understanding the role of retinoic acid signalling and metabolism in health and disease. Retinoic acid (RA) is the active metabolite of vitamin A and has several important physiological functions including regulation of cell proliferation and apopto...
The main research focus in the Petkovich lab is understanding the role of retinoic acid signalling and metabolism in health and disease. Retinoic acid (RA) is the active metabolite of vitamin A and has several important physiological functions including regulation of cell proliferation and apoptosis, cell differentiation, and tissue morphogenesis. These attributes of RA have been exploited in the clinic for the treatment of skin diseases and make it a strong candidate for cancer prevention and differentiation therapy.