Paul Soloway, Cornell University
Professor
Ithaca, New York
soloway@cornell.edu
Office:
(607) 254-6444
Expert In
Bio/Research
Current research activities are in the area of epigenetics and includes several separate sets of projects. One of these seeks to characterize the mechanisms regulating the epigenetic phenomena of DNA and histone methylation in mice using the Rasgrf1 gene as a model. These methylation events are...
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Bio/Research
Current research activities are in the area of epigenetics and includes several separate sets of projects. One of these seeks to characterize the mechanisms regulating the epigenetic phenomena of DNA and histone methylation in mice using the Rasgrf1 gene as a model. These methylation events are potent regulators of gene expression and respond to environmental variables, including nutrition, in ways that are stable and inheritable. A second set of projects seeks to develop next generation methods for single molecule profiling of multiple epigenetic states, simultaneously and genome wide. A third project has characterized epigenetic mechanisms controlling poly A site usage in mammalian cells. A fourth and new project is a collaboration with Prof. Barbara Strupp to characterize epigenomic mechanisms by which maternal choline supplementation leads to improved cognitive outcomes in the progeny. Recent advances in epigenomic methods make this project tractable.
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