The laboratory of Dr. Peter S. McPherson, James McGill Professor uses biochemical, molecular, structural and cellular approaches to identify and functionally characterize proteins that function in membrane trafficking in neurons.
A number of the proteins identified in the McPherson labo...
The laboratory of Dr. Peter S. McPherson, James McGill Professor uses biochemical, molecular, structural and cellular approaches to identify and functionally characterize proteins that function in membrane trafficking in neurons.
A number of the proteins identified in the McPherson laboratory have been linked to neurological diseases including schizophrenia, Huntington's disease, hereditary spastic paraplegias (ALS-like), and autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS). Indeed, dysregulation of membrane trafficking is emerging as a central theme in neurodegenerative diseases. Understanding the cell biological basis of neurological disease is a focus of the laboratory.