Peter Paré, University of British Columbia
Medicine
Professor
Vancouver, British Columbia
peter.pare@hli.ubc.ca
Office:
(604) 682-2344 ext. 62750
Expert In
Bio/Research
Dr. Pare’s research expertise is in the study of the pathophysiology and genetics of asthma, Chronic Obstructive Pulmonary Disease (COPD) and Cystic Fibrosis.
Bronchoconstriction in response to non-specific stimuli is a characteristic feature of human asthma and it occurs in other obstru...
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Bronchoconstriction in response to non-specific stimuli is a characteristic feature of human asthma and it occurs in other obstru...
Click to Expand >>
Bio/Research
Dr. Pare’s research expertise is in the study of the pathophysiology and genetics of asthma, Chronic Obstructive Pulmonary Disease (COPD) and Cystic Fibrosis.
Bronchoconstriction in response to non-specific stimuli is a characteristic feature of human asthma and it occurs in other obstructive airway diseases. Dr. Pare and his colleague Dr. Dr. Chun Seow are actively investigating the molecular and biomechanical events which relate bronchoconstricting stimuli to the ultimate airway narrowing that occurs. In vitro studies from their laboratory using tracheal smooth muscle from various mammalian species, including human, have shown that a decrease in the load impeding smooth muscle shortening can have a profound influence on the degree to which the airways will narrow. In ongoing work they are examining isotonic and isometric length-tension properties of smooth muscle and investigating the remarkable plastic behaviour of smooth muscle using physiologic, morphologic and biochemical approaches.
With Dr. J.C. Hogg, Pare developed an internationally unique lung tissue biobank which now contains over 6,000 samples of fixed and frozen lung tissue. The biobank has been a rich source of material for studies of the relationship of lung structure and function and frozen lung samples are being used for genetic and molecular biology studies to identify novel targets for lung disease.
With colleagues Drs. Harvey Coxson, John Mayo and Nestor Muller Dr. Pare is investigating the application of high resolution CT scanning in the assessment of emphysema and airway disease.
Dr. Pare studies Gene-Environment interaction in the pathogenesis of inflammatory diseases of the Heart, Lung and Blood Vessels. Specifically he and his collaborators are studying Chronic Obstructive Pulmonary Disease, Asthma and Calcific Aortic Stenosis. Co investigators include Drs. Bruce McManus and Andrew Sandford.
Dr Pare is a leader of the Genes and Environment Program of the AllerGen National Centre of Excellence and works with co-investigators including Dr Denise Daley to find susceptibility genes for allergic disease.
Drs. Pare and Sandford are co-investigators of a Genome Canada/Ontario project to study genetic modifiers of Cystic Fibrosis. Drs. Lap-Chee Tsui, Peter Durie, Julian Zielinski and Mare Corey are co-investigators on this project.
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Bronchoconstriction in response to non-specific stimuli is a characteristic feature of human asthma and it occurs in other obstructive airway diseases. Dr. Pare and his colleague Dr. Dr. Chun Seow are actively investigating the molecular and biomechanical events which relate bronchoconstricting stimuli to the ultimate airway narrowing that occurs. In vitro studies from their laboratory using tracheal smooth muscle from various mammalian species, including human, have shown that a decrease in the load impeding smooth muscle shortening can have a profound influence on the degree to which the airways will narrow. In ongoing work they are examining isotonic and isometric length-tension properties of smooth muscle and investigating the remarkable plastic behaviour of smooth muscle using physiologic, morphologic and biochemical approaches.
With Dr. J.C. Hogg, Pare developed an internationally unique lung tissue biobank which now contains over 6,000 samples of fixed and frozen lung tissue. The biobank has been a rich source of material for studies of the relationship of lung structure and function and frozen lung samples are being used for genetic and molecular biology studies to identify novel targets for lung disease.
With colleagues Drs. Harvey Coxson, John Mayo and Nestor Muller Dr. Pare is investigating the application of high resolution CT scanning in the assessment of emphysema and airway disease.
Dr. Pare studies Gene-Environment interaction in the pathogenesis of inflammatory diseases of the Heart, Lung and Blood Vessels. Specifically he and his collaborators are studying Chronic Obstructive Pulmonary Disease, Asthma and Calcific Aortic Stenosis. Co investigators include Drs. Bruce McManus and Andrew Sandford.
Dr Pare is a leader of the Genes and Environment Program of the AllerGen National Centre of Excellence and works with co-investigators including Dr Denise Daley to find susceptibility genes for allergic disease.
Drs. Pare and Sandford are co-investigators of a Genome Canada/Ontario project to study genetic modifiers of Cystic Fibrosis. Drs. Lap-Chee Tsui, Peter Durie, Julian Zielinski and Mare Corey are co-investigators on this project.
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