Our long-range goal is to gain insight into the mechanisms governing the release and actions of neurotransmitters. In recent years it has become clear that most neurons use multiple transmitters, commonly a single fast acting conventional transmitter and one or more peptide transmitters. While mu...
Our long-range goal is to gain insight into the mechanisms governing the release and actions of neurotransmitters. In recent years it has become clear that most neurons use multiple transmitters, commonly a single fast acting conventional transmitter and one or more peptide transmitters. While much research has focused on conventional transmitters, large gaps exist in our knowledge of the biology of neuropeptides at all stages from release to physiological function. We are currently using a number of tools including single cell biochemistry, electrophysiology, cell culture, and immunocytochemistry to identify novel transmitters and study their actions.