Raja Ghosh, McMaster University

Assistant Professor Chemical Engineering Hamilton, Ontario rghosh@mcmaster.ca Office: (905) 525-9140 ext. 27415

Bio/Research

Bioseparation using ultrafiltration: Development of efficient, scalable, high-resolution purification processes is essential for cost-effective bio-pharmaceutical manufacturing. We are working on techniques for rapid optimization of ultrafiltration processes and on the development of novel and ef...

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Bio/Research

Bioseparation using ultrafiltration: Development of efficient, scalable, high-resolution purification processes is essential for cost-effective bio-pharmaceutical manufacturing. We are working on techniques for rapid optimization of ultrafiltration processes and on the development of novel and efficient cascade ultrafiltration systems for purification of serum and monoclonal antibodies. Other interests include development of smart environment responsive membranes and study of membrane fouling.

Bioseparation using membrane chromatography: Our interests include the development of economic and efficient paper based adsorptive membranes and the design of novel membrane adsorption devices. Typical applications we are currently working on include monoclonal antibody purification, antibody aggregate separation, purification of therapeutic proteins from transgenic tobacco and plasma protein purification.

Hybrid bioseparations:We have developed of a novel hybrid bioseparation technique based on the combination of protein precipitation, sieving and hydrophobic interaction membrane adsorption for high resolution separation of antibodies. Typical applications include monoclonal antibody purification, hyper-immune antibody production and plasma fractionation.

Membrane based analytical bioseparations:We developed a novel and efficient method for detecting and analyzing antibody aggregates based on the use of hydrophobic interaction membranes. We are also working on efficient way of using membranes for immunoassays – in a membrane chromatographic mode. This approach has opened up some new opportunities such as rapid multi-target testing which are being explored.



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