The overall goal of my research has been to understand the remarkable mechanisms that account for the control and integration of intermediary metabolism. I have been especially interested in the control of fatty acid metabolism by insulin, adrenaline and other hormones, with a special focus on th...
The overall goal of my research has been to understand the remarkable mechanisms that account for the control and integration of intermediary metabolism. I have been especially interested in the control of fatty acid metabolism by insulin, adrenaline and other hormones, with a special focus on the enzyme acetyl-CoA carboxylase. This general interest began with an undergraduate project looking at the control of glycogen synthesis in yeast, a project that was followed by my graduate studies of fatty acid metabolism in the heart. My interests in acetyl-CoA carboxylase began with post-doctoral studies and have continued ever since. My specific interests have come full circle with a renewed opportunity to study heart metabolism, especially through collaborative projects with UBC colleagues Michael Allard, Jim Johnson, John McNeill, Kathleen MacLeod and Brian Rodrigues.