Rosie Redfield, University of British Columbia
Associate Professor
Zoology
Vancouver, British Columbia
redfield@interchange.ubc.ca
Office:
(604) 822-3744
(604) 822-6323
Bio/Research
We have recently identified the components of the H. influenzae competence regulon (25 genes in 13 transcription units). We've also found that this regulon is ancestral in many related pathogens including Escherichia coli and Vibrio cholerae, suggesting that many more bacteria may be naturally co...
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Bio/Research
We have recently identified the components of the H. influenzae competence regulon (25 genes in 13 transcription units). We've also found that this regulon is ancestral in many related pathogens including Escherichia coli and Vibrio cholerae, suggesting that many more bacteria may be naturally competent than previously thought. At the heart of the regulon is an entirely novel mode of regulation by CRP, in which the competence-specific inducer protein Sxy directs CRP to activate transcription at a new class of CRP sites. The nutritional signals we've identified suggest that DNA is more valuable for its nucleotides than for its genetic information.
Our ongoing research uses the tools of molecular biology, bioinformatics and evolutionary biology. We culture bacteria, run DNA, RNA and protein gels, align sequences and search for motifs, test DNAs and proteins for interactions, write and run Perl programs, analyze real-time PCR and microarray results, and even tie DNA down with laser tweezers (with some help from our physicist friends). You can read more about our research plans in our grant proposals (what we're planning), you can read our research blogs to see what we're currently working on (what we're doing), and you can read the papers we've published (what we've done).
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Our ongoing research uses the tools of molecular biology, bioinformatics and evolutionary biology. We culture bacteria, run DNA, RNA and protein gels, align sequences and search for motifs, test DNAs and proteins for interactions, write and run Perl programs, analyze real-time PCR and microarray results, and even tie DNA down with laser tweezers (with some help from our physicist friends). You can read more about our research plans in our grant proposals (what we're planning), you can read our research blogs to see what we're currently working on (what we're doing), and you can read the papers we've published (what we've done).
Click to Shrink <<