Bio/Research
I am interested in the application of computational technologies to problems in molecular biology of relevance to medicine. In particular, my laboratory focuses on drug response at the molecular level, working in three areas. First, we are building a comprehensive pharmacogenomics knowledge base ...
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Bio/Research
I am interested in the application of computational technologies to problems in molecular biology of relevance to medicine. In particular, my laboratory focuses on drug response at the molecular level, working in three areas. First, we are building a comprehensive pharmacogenomics knowledge base (http://www.pharmgkb.org/) that provides access to information relating genotype to phenotype (in particular, how variation in genetics leads to variation in response to drugs). We are interested in collaboratively discovering and applying new pharmacogenomics knowledge. Second, we are interested in the analysis of three dimensional biological structures. We have methods for analyzing protein structures to recognize and annotate active sites and binding sites, particularly in the context of interactions with small molecule drugs. We are also interested in physics-based simulation of biological structures to understand how their dynamics impact their function (http://simbios.stanford.edu/). Finally, we are interested in computational methods for analyzing functional genomics information. We use natural language processing techniques for extracting and summarizing information in the literature, chemoinformatics methods for understanding small molecule function, and machine learning & data mining techniques to understand the molecular responses to drugs.
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