Serge Lemay, McGill University
Assistant Professor
Cancer Research Unit
Nephrology
Montreal, Quebec
serge.lemay@mcgill.ca
Office:
(514) 934-1934 ext. 76198
Bio/Research
Our aim is to characterize novel tyrosine kinase signaling pathways in epithelial cells and to define their role in ischemic renal injury and proteinuric diseases. We have a particular interest in two distinct molecules, the novel adapter protein Dok-4 and the receptor tyrosine kinase EphA2. Dok-...
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Bio/Research
Our aim is to characterize novel tyrosine kinase signaling pathways in epithelial cells and to define their role in ischemic renal injury and proteinuric diseases. We have a particular interest in two distinct molecules, the novel adapter protein Dok-4 and the receptor tyrosine kinase EphA2. Dok-4 is a newly discovered adapter molecule that is a substrate for tyrosine kinases of the Src family and for a restricted number of receptor tyrosine kinases, including Ret. Its physiological role is still under investigation, but our laboratory has been the first to develop an antibody against this molecule and to recognize its prominent expression in epithelial cells as a constitutively membrane-associated molecule capable of inhibiting Erk/Elk-1 signaling. Eph family receptors have been extensively characterized during embryonic development, particularly in the central nervous system. They have many unique properties, including mediation of cell-cell repulsion and actin cytoskeleton remodeling. The fact that some members of this family are highly expressed in adult tissues is only beginning to be seriously recognized. We think that some Eph family members, particularly EphA2, may have important roles in the functional recovery of renal tubular cells following ischemic injury.
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