Bio/Research
Dr. Sanders' molecular neuroscience lab is interested in how neurons use the protein-lipid modification palmitoylation to target proteins to specific subcellular locations and to define how palmitoylation-dependent targeting contributes to physiological neuronal function and neuropathological con...
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Bio/Research
Dr. Sanders' molecular neuroscience lab is interested in how neurons use the protein-lipid modification palmitoylation to target proteins to specific subcellular locations and to define how palmitoylation-dependent targeting contributes to physiological neuronal function and neuropathological conditions.
Sanders' lab is particularly interested in how palmitoylation of ion channels and trafficking machinery regulates sub-neuronal targeting of proteins and, in turn, neuronal function.
Her lab uses cutting-edge genetic, biochemical, and cell biological approaches to answer these questions, including CRISPR-mediated gene knockout and mutation, shRNA-mediated knockdown and rescue, specialized palmitoylation assays, and live and fixed confocal microscopy in neurons grown in conventional culture and in microfluidic devices.
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Sanders' lab is particularly interested in how palmitoylation of ion channels and trafficking machinery regulates sub-neuronal targeting of proteins and, in turn, neuronal function.
Her lab uses cutting-edge genetic, biochemical, and cell biological approaches to answer these questions, including CRISPR-mediated gene knockout and mutation, shRNA-mediated knockdown and rescue, specialized palmitoylation assays, and live and fixed confocal microscopy in neurons grown in conventional culture and in microfluidic devices.
Click to Shrink <<