Bio/Research
The primary goal of Golovkina’s laboratory is to understand how the innate immune system detects retroviral infection and initiates virus-neutralizing adaptive immune responses. In addition, she is also interested in mechanisms evolved by retroviruses to overcome host protective responses. To i...
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Bio/Research
The primary goal of Golovkina’s laboratory is to understand how the innate immune system detects retroviral infection and initiates virus-neutralizing adaptive immune responses. In addition, she is also interested in mechanisms evolved by retroviruses to overcome host protective responses. To investigate these important questions, Golovkina’s lab employ virus-resistant mice capable of controlling retroviruses from distinct genera. Using mice from retrovirus-resistant strains, her lab found that endosomal Toll-like receptor 7 (TLR7) is an innate immune receptor that detects mouse retroviruses and signals to stimulate the production of virus-neutralizing antibodies (Kane et al, Immunity 2011).
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