Dr. Coderre's laboratory is interested in understanding the mechanisms underlying nociceptive plasticity in spinal cord and brain important for the transition from acute to persistent pain. Currently, investigations are assessing the role of protein kinase M-zeta in the maintenance of neuronal pa...
Dr. Coderre's laboratory is interested in understanding the mechanisms underlying nociceptive plasticity in spinal cord and brain important for the transition from acute to persistent pain. Currently, investigations are assessing the role of protein kinase M-zeta in the maintenance of neuronal pain memory traces, and the contribution of nuclear metabotropic glutamate receptors to persistent pain. Additional research is aimed at developing animal models of chronic pain to provide a basis for mechanism- based therapeutic treatments. Currently, investigations are examing the role of microvascular dysfunction in animal models of complex regional pain syndrome and painful diabetic neuropathy.