Dr. Blank is an internationally recognized researcher in the fields of erythropoiesis and cancer.
He participated in the first cloning and analysis of NF-kB, a transcriptional regulator that plays a key role in immunity and infection.
He is known for his studies on CNC and Maf transcription factor family members that play important roles in mammalian differentiation, oncogenesis and stress response.
Dr. Blank’s laboratory is interested in the functions of the CNC and small Maf basic-leucine zipper transcription factors. The research team he leads has the following objectives: 1) Analyze the molecular mechanisms that regulate the differentiation of erythroid cells, with particular emphasis on the p45 NF-E2 transcription factor; 2) Determine the role of the Nrf3 transcription factor in mammalian gene regulation; 3) Examine the regulation of the MafF protein in proinflammatory cytokine signaling. The long-term goal of these studies is to design novel treatment options for patients with erythroid cell disorders and cancer.